A viral over-expression system for the major malaria mosquito Anopheles gambiae
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منابع مشابه
A viral over-expression system for the major malaria mosquito Anopheles gambiae
Understanding pathogen/mosquito interactions is essential for developing novel strategies to control mosquito-borne diseases. Technical advances in reverse-genetics, such as RNA interference (RNAi), have facilitated elucidation of components of the mosquito immune system that are antagonistic to pathogen development, and host proteins essential for parasite development. Forward genetic approach...
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Females of the malaria-carrying mosquito, Anopheles gambiae, must deal with a number of tasks never confronted by males, including blood-feeding and defense against Plasmodium infection. Here, we examine global gene expression differences between the sexes in A. gambiae via Affymetrix GeneChip® microarrays and find a dramatic over-representation of genes expressed more highly in females. Approx...
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Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes more than 1 million deaths each year. Tenfold shotgun sequence coverage was obtained from the PEST strain of A. gambiae and assembled into scaffolds that span 278 million base pairs. A total of 91% of the genome was organized in 303 scaffolds; the largest scaffold was 23.1 milli...
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Mosquitoes are vectors for multiple infectious human diseases and use a variety of sensory cues (olfactory, temperature, humidity and visual) to locate a human host. A comprehensive understanding of the circuitry underlying sensory signalling in the mosquito brain is lacking. Here we used the Q-system of binary gene expression to develop transgenic lines of Anopheles gambiae in which olfactory ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2014
ISSN: 2045-2322
DOI: 10.1038/srep05127